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Hyperbaric oxygen therapy and piracetam decrease the early extension of deep partial-thickness burns

P Germonpré1, P Reper, A Vanderkelen

  • 1Center for Hyperbaric Oxygen Therapy, Military Hospital Queen Astrid, Bŕussels, Belgium.

Burns : Journal of the International Society for Burn Injuries
|September 1, 1996
PubMed
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Hyperbaric oxygen therapy (HBOT) and piracetam treatments show promise in preventing early burn wound progression in rats. HBOT demonstrated significant anti-inflammatory effects by reducing leucocyte infiltration, suggesting potential for further research.

Area of Science:

  • Biomedical Engineering
  • Wound Healing Research
  • Pharmacology

Background:

  • Burn wound progression in the initial 24 hours is a significant clinical challenge.
  • Standard fluid resuscitation and dressings offer only partial prevention of early burn wound deepening.
  • Novel therapeutic strategies are needed to mitigate early burn wound progression.

Purpose of the Study:

  • To evaluate the efficacy of hyperbaric oxygen therapy (HBOT) and piracetam in preventing early burn wound progression in a rat model.
  • To compare the histological effects of HBOT and piracetam on burn wound depth, epidermal basal membrane preservation, skin appendage destruction, and subepidermal inflammation.

Main Methods:

  • A rat model of 5% total body surface area (TBSA) burn was used.
  • Animals received standard burn wound treatment with mafenide 10% solution humid dressings.

Related Experiment Videos

  • Groups included a control, HBOT (203 kPa, 60 min twice daily), and piracetam (200 mg/kg IM twice daily).
  • Histological examination of excised burn wounds was performed on day three.

    • Main Results:

    • Both HBOT and piracetam significantly preserved the epidermal basal membrane (P < 0.001 and P < 0.01, respectively).
    • HBOT significantly reduced skin appendage destruction (P ≤ 0.05) and subepidermal leucocyte infiltration (P < 0.001).
    • Piracetam did not show significant effects on skin appendage destruction (P > 0.05) or leucocyte infiltration (P > 0.05).
    • HBOT group exhibited significantly less leucocyte infiltration compared to the piracetam group (P < 0.01).

    Conclusions:

    • HBOT and piracetam show potential in preserving epidermal basal membranes in burn wounds.
    • HBOT demonstrates significant anti-inflammatory effects by reducing leucocyte infiltration, surpassing piracetam's effect.
    • The anti-inflammatory properties of HBOT warrant further investigation for clinical application in burn wound management.