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Updated: Aug 10, 2026
A Rat Model of Compound Acne
Published on: November 1, 2024
Oral 9-cis-retinoic acid versus 13-cis-retinoic acid in acne therapy
1F. Hoffmann-La Roche Ltd, Basel, Switzerland.
Background:
9-cis-Retinoic acid (9-cis-RA) is as active as 13-cis-retinoic acid (13-cis-RA) in inhibiting the proliferation of cultured human sebocytes and in reducing the size of sebaceous glands of hamsters.
Objective:
Evaluate the anti-acne effect of 9-cis-RA compared to that of 13-cis-RA in a pilot study.
Methods:
Four young male patients with acne were treated in an open study consecutively with 9-cis-RA and 13-cis-RA given at similar doses.
Results:
No beneficial effects were observed with 9-cis-RA in any of the patients whereas all responded favorably to 13-cis-RA.
Conclusion:
For the two retinoids tested, the anti-acne effect correlates with the sebosuppressive effect in humans.
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