Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulation of gap junction coupling in the developing neocortex

B Rörig1, B Sutor

  • 1Institute of Physiology, University of Munich, Germany.

Molecular Neurobiology
|June 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Neuronal nicotinic acetylcholine receptors and autosomal dominant nocturnal frontal lobe epilepsy: a critical review.

Pflugers Archiv : European journal of physiology·2001
Same author

Assessment and management of behavioral disturbances in nursing home patients with dementia.

Mayo Clinic proceedings·2001
Same author

Electroconvulsive therapy-responsive depression in a patient with progressive supranuclear palsy.

The journal of ECT·2001
Same author

Conveying emotional realism: a challenge to using standardized patients.

Academic medicine : journal of the Association of American Medical Colleges·2001
Same author

Activation of mu- and delta-opioid receptors causes presynaptic inhibition of glutamatergic excitation in neocortical neurons.

Anesthesiology·2000
Same author

Myelination defects and neuronal hyperexcitability in the neocortex of connexin 32-deficient mice.

Cerebral cortex (New York, N.Y. : 1991)·2000

Gap junctions in the developing neocortex are vital for forming neural circuits. Neurotransmitters like dopamine and serotonin modulate this communication, influencing synaptic potential integration and circuit refinement.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Cellular Communication

Background:

  • Gap junctions form transient metabolic and electrical communication systems in the developing mammalian neocortex.
  • These junctions are hypothesized to play a critical role in neocortical synaptic circuit formation and refinement.

Purpose of the Study:

  • To examine the influence of gap junctions on electrotonic cell properties and synaptic potential integration.
  • To investigate the regulation of gap junctional communication by neurotransmitters through second messenger pathways.

Main Methods:

  • Analysis of electrotonic cell properties and their impact on synaptic potential integration.
  • Investigation of neurotransmitter-mediated regulation of gap junction coupling via cAMP and IP3 signaling pathways.

Related Experiment Videos

  • Exploration of the nitric oxide (NO)/cGMP system's role in modulating gap junction communication.

    • Main Results:

    • Gap junctions significantly influence the electrotonic characteristics of postsynaptic neurons, thereby affecting chemical synaptic input efficacy.
    • Monoaminergic neuromodulators (dopamine, noradrenaline, serotonin) reduce gap junction coupling through distinct intracellular signaling cascades.
    • The NO/cGMP system modulates gap junctional communication, potentially linking glutamatergic transmission to the gap junction network.

    Conclusions:

    • Gap junctions are crucial for modulating neuronal integration and synaptic efficacy during neocortical development.
    • Neurotransmitter systems dynamically regulate gap junction communication, impacting circuit formation.
    • The NO/cGMP pathway provides a potential link between developing synaptic transmission and gap junction networks, highlighting their importance in circuit refinement.