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Related Experiment Videos

Exercise-associated amenorrhea, low bone density, and estrogen replacement therapy

D C Cumming1

  • 1Department of Obstetrics and Gynaecology, University of Alberta, Edmonton. dcumming@gpu.srv.ualberta.ca

Archives of Internal Medicine
|October 28, 1996
PubMed
Summary

Hormone replacement therapy significantly increased bone density in women with exercise-associated amenorrhea. This study suggests hormone therapy is an effective treatment for osteoporosis in amenorrheic runners.

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Area of Science:

  • Exercise physiology
  • Endocrinology
  • Bone metabolism

Background:

  • Women experiencing exercise-associated amenorrhea exhibit higher osteoporosis rates compared to eumenorrheic runners and sedentary individuals.
  • Hormone replacement therapy (HRT) has been previously proposed to enhance bone density in exercising women with amenorrhea and low bone mass.

Purpose of the Study:

  • To investigate the efficacy of hormone replacement therapy in improving bone density among women with exercise-associated amenorrhea.

Main Methods:

  • A retrospective clinical study was conducted.
  • Bone density changes were compared between 8 women runners with amenorrhea who received HRT and 5 control women who declined medication over a 24–30 month period.

Main Results:

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  • Women undergoing HRT showed significant increases in vertebral bone density (8.0% ± 1.2%) and femoral neck bone density (4.1% ± 0.3%).
  • Control subjects not receiving HRT experienced non-significant bone density decreases (<2.5%) at both sites.

Conclusions:

  • Hormone replacement therapy demonstrates a positive effect on bone density in amenorrheic runners.
  • HRT may be a beneficial intervention for managing low bone density in this population.