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Related Experiment Videos

Soft tissue sarcomas

J J Lewis1, M F Brennan

  • 1Department of Surgery, Memorial Sloan-Kettering Cancer Center, Cornell University Medical College New York, New York, USA.

Current Problems in Surgery
|October 1, 1996
PubMed
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Soft tissue sarcomas require surgical resection. Adjuvant radiation improves local control for high-risk patients, and recurrence treatment can be effective, though advanced disease has a poor prognosis.

Area of Science:

  • Oncology
  • Surgical Oncology
  • Radiation Oncology

Background:

  • Soft tissue sarcomas are rare tumors with an incidence of 5000-6000 annually in the US.
  • Primary treatment involves surgical resection with adequate margins.
  • Postoperative adjuvant radiation improves local control in high-risk cases.

Purpose of the Study:

  • To review the management and treatment outcomes for soft tissue sarcomas.
  • To discuss local recurrence and metastatic disease in soft tissue sarcomas.
  • To outline therapeutic strategies based on disease extent and location.

Main Methods:

  • Review of treatment modalities for soft tissue sarcomas.
  • Analysis of local recurrence rates and outcomes for extremity lesions.

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  • Evaluation of management for pulmonary and extrapulmonary metastases.

    • Main Results:

    • Local recurrence rates vary by anatomic site, with extremity lesions recurring in one-third of patients.
    • Treatment for local recurrence in extremities can yield results similar to primary disease.
    • Resection of isolated pulmonary metastases offers a 20-30% 3-year survival rate.

    Conclusions:

    • Surgical resection and adjuvant radiation are key for local control of soft tissue sarcomas.
    • Management of recurrent or metastatic disease presents challenges, particularly in non-extremity sites.
    • Systemic chemotherapy is the primary option for unresectable or extrapulmonary metastatic disease, offering a poor prognosis.