Fate of Schistosoma mansoni in Biomphalaria obstructa

Histological sections of Biomphalaria obstructa snails exposed to miracidia of Schistosoma mansoni revealed that although viable sporocysts occurred in 6 of 9 snails at 3 days postexposure (DPE), all were dead by 7 DPE. Most dead sporocysts appeared to have degenerated slowly rather than having been killed by host hemocytic responses, which were minimal. What appeared to be amorphous remnants of sporocysts could still be found at 31 DPE. In 7 of 10 snails infected simultaneously with S. mansoni and Echinostoma paraensei, viable schistosome sporocysts occurred at 7 DPE, possibly as a result of interference with hemocyte function by the echinostome. However, in snails exposed to E. paraensei 48 hr prior to S. mansoni, no viable schistosome sporocysts were found at 7 DPE. Biomphalaria obstructa may be only temporarily susceptible to infection with E. paraensei, rediae of which undergo degeneration, hemocyte-mediated destruction, or both by 7-9 DPE.