Leydig cell hyperplasia mimicking testicular neoplasm
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Updated: Oct 12, 2026

Germ Cell Transplantation and Testis Tissue Xenografting in Mice
Published on: February 6, 2012
A F Olumi1, M B Garnick, A A Renshaw
1Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Abstract:
Patients with extragonadal seminoma are at high risk of developing a primary testicular neoplasm many years after the initial diagnosis and therapy. Therefore, long-term follow-up is critical in the proper management of these patients. We present the first case of Leydig cell hyperplasia, mimicking a testicular neoplasm, 21 years after diagnosis and treatment of extragonadal seminoma.
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