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Histopathologic characterization of hereditary benign prostatic hyperplasia
C B Doehring1, M G Sanda, A W Partin
1James Buchanan Brady Urological Institute, Johns Hopkins Hospital and School of Medicine, Baltimore, Maryland, USA.
Urology
|October 1, 1996
Summary
Hereditary benign prostatic hyperplasia (H-BPH) in younger men shows a higher stromal/epithelial ratio compared to sporadic BPH in older men. This suggests H-BPH may involve increased stromal tissue growth.
Area of Science:
- Urology
- Pathology
- Genetics
Background:
- Benign prostatic hyperplasia (BPH) is common in older men.
- Recent evidence suggests a hereditary form of BPH (H-BPH).
- Histopathologic differences between H-BPH and sporadic BPH are not well-characterized.
Purpose of the Study:
- To characterize the histopathologic features of H-BPH.
- To compare the stromal/epithelial ratio in H-BPH with control groups.
Main Methods:
- Histologic sections from 12 men with H-BPH were analyzed.
- Morphometric analysis of stromal/epithelial ratios was performed using color video image analysis.
- Comparisons were made with age-matched and prostate weight-matched control groups.
Main Results:
- Men with H-BPH had a mean stromal/epithelial ratio of 2.6 +/- 1.4.
- This ratio was significantly higher than in prostate weight-matched controls (1.7 +/- 0.9, P = 0.015).
- No significant difference was found compared to age-matched controls (2.7 +/- 1.7, P = 0.36).
Conclusions:
- Younger men with H-BPH exhibit a higher stromal/epithelial ratio than older men with sporadic BPH of similar prostate size.
- This suggests that H-BPH may be associated with an increased proportion of stromal elements in the prostate.