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Dopamine DRD2/Cys311 is not associated with chronic schizophrenia
1Roskamp Laboratories, University of South Florida, Tampa 33613, USA.
American Journal of Medical Genetics
|September 20, 1996
Summary
A specific mutation in the dopamine D2 receptor (DRD2) gene, Cys311, was investigated for its link to schizophrenia in US Caucasians. This study found no significant association between the DRD2 Cys311 variant and schizophrenia in this population.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- A mutation in the dopamine D2 receptor (DRD2) gene, specifically Ser to Cys at codon 311, has been previously associated with schizophrenia in Japanese and Caucasian individuals.
- This variation occurs in the third intracellular loop of the DRD2 receptor, suggesting a potentially functional role in the receptor's activity.
Purpose of the Study:
- To investigate the association between the DRD2 Cys311 variant and schizophrenia in a US Caucasian population.
- To determine if the frequency of the DRD2 Cys311 variant differs between schizophrenic patients and healthy controls in this demographic.
Main Methods:
- Screening of US Caucasian schizophrenic and non-schizophrenic (control) populations.
- Genotyping to detect the presence of the DRD2 Cys311 variant.
Main Results:
- The DRD2 Cys311 variant was detected in both the schizophrenic and control groups within the US Caucasian population.
- Statistical analysis revealed no significant difference in the frequency of the Cys311 variant between Caucasian schizophrenics and non-schizophrenics.
Conclusions:
- The DRD2 Cys311 variant is not significantly associated with schizophrenia in the US Caucasian population studied.
- These findings suggest that this specific DRD2 gene variation may not be a contributing genetic factor for schizophrenia in this demographic.