Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

MRI brain abnormalities in chronic schizophrenia: one process or more?

B T Woods1, D Yurgelun-Todd, J M Goldstein

  • 1Department of Neurology, Texas A & M Medical School, Temple, USA.

Biological Psychiatry
|October 1, 1996
PubMed
Summary

Schizophrenia may involve brain volume loss in frontal regions before development is complete, and widespread tissue loss after brain growth has ended. This study investigated brain volume changes in schizophrenia patients.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Weight gain and brain development in the ABCD study cohort: A decade of insight and the road ahead.

Developmental cognitive neuroscience·2026
Same author

MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.

International journal of clinical and health psychology : IJCHP·2024
Same author

Anatomical and fMRI-network comparison of multiple DLPFC targeting strategies for repetitive transcranial magnetic stimulation treatment of depression.

Brain stimulation·2021
Same author

Targeting location relates to treatment response in active but not sham rTMS stimulation.

Brain stimulation·2021
Same author

Sex-dependent associations of maternal androgen levels with offspring BMI and weight trajectory from birth to early childhood.

Journal of endocrinological investigation·2020
Same author

Multiple ipsilateral femoral stress fractures in a patient taking denosumab for osteoporosis-a case report.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2020

Area of Science:

  • Neuroscience
  • Psychiatry
  • Radiology

Background:

  • Schizophrenia is hypothesized to be a disorder of prefrontal-temporal-limbic circuitry.
  • The underlying neuropathology may originate during early brain development and is potentially non-progressive.

Purpose of the Study:

  • To investigate whether brain volume losses in schizophrenia occur before or after brain growth is complete.
  • To differentiate between early developmental deficits and later progressive changes in brain structure.

Main Methods:

  • Magnetic Resonance Imaging (MRI) was used to scan 19 chronic schizophrenic patients and 19 healthy controls.
  • Scans were segmented into gray matter, white matter, and cerebrospinal fluid (CSF) for specific brain regions.
  • Multivariate analysis of variance (MANOVA) analyzed absolute volumes and tissue-to-intracranial volume (TCV) ratios.

Related Experiment Videos

Main Results:

  • Schizophrenia patients exhibited significant intracranial volume reductions specifically in the frontal lobes.
  • Patients displayed significantly lower TCV ratios across all major brain regions, indicating greater relative tissue loss.
  • Frontal lobe volume decreases suggest a pathologic process impacting these areas before brain maturation.

Conclusions:

  • Observed frontal lobe volume reductions in schizophrenia may indicate an early developmental impact.
  • Generalized lower TCV ratios suggest a separate, whole-brain process occurring after brain volume has reached its maximum.
  • These findings contribute to understanding the complex developmental and potentially progressive neuropathology in schizophrenia.