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Plasma follistatin concentrations increase following lipopolysaccharide administration in sheep
R Klein1, I J Clarke, M P Hedger
1Department of Anatomy and Physiology, Royal Melbourne Institute of Technology, Bundoora, Australia.
Clinical and Experimental Pharmacology & Physiology
|August 1, 1996
Abstract:
1. The effect of inflammation induced by lipopolysaccharide (LPS) injection on plasma follistatin (FS) concentrations was investigated. 2. Plasma FS and tumour necrosis factor-alpha concentrations increase following LPS administration in ewes. 3. The rise in FS is similar, but more sustained, to that previously observed after surgery. 4. These results indicate a possible functional link between FS, inflammation and the acute-phase response.