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Summary
Nasal allergy and hay fever patients exhibit increased submucous gland density, indicating new abnormal glands form. This suggests existing glands are the primary source of increased nasal secretion in allergic rhinitis.
Area of Science:
- Otorhinolaryngology
- Allergology
- Pathoanatomy
Background:
- Nasal allergy and hay fever are common conditions characterized by inflammation of the nasal mucosa.
- The role of submucous glands in the pathophysiology of allergic rhinitis is not fully understood.
Purpose of the Study:
- To investigate the density and morphology of submucous glands in the nasal mucosa of a patient with nasal allergy and hay fever.
- To determine the contribution of submucous glands to the increased nasal secretion observed in allergic conditions.
Main Methods:
- Whole mount method applied to the entire nasal mucosa.
- Quantitative determination of submucous gland density.
- Morphological analysis of submucous glands.
Main Results:
- Submucous gland density was significantly higher in all nasal regions compared to normal.
- Gland density was particularly elevated on the nasal conchae.
- New, morphologically distinct abnormal glands were identified in the diseased mucosa.
Conclusions:
- The increased density and formation of abnormal submucous glands provide a pathoanatomical basis for enhanced secretory capacity in allergic rhinitis.
- Existing submucous glands are likely the exclusive source of increased nasal secretion during allergic episodes.
- Further research is needed to elucidate the mechanisms of gland formation and their precise role in nasal allergy.