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Serum interleukin-6 levels after urologic operations

T Igarashi1, H Takahashi, M Tanaka

  • 1Department of Urology, Asahi General Hospital, Chiba, Japan.

International Journal of Urology : Official Journal of the Japanese Urological Association
|September 1, 1996
PubMed
Summary

Minimally invasive surgeries like endourology, ESWL, and laparoscopy show lower systemic reactions. Serum interleukin-6 (IL-6) levels confirm reduced operative invasiveness compared to open surgery.

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Area of Science:

  • Urology
  • Surgical Oncology
  • Minimally Invasive Surgery

Background:

  • Minimally invasive procedures like endourology, extracorporeal shock wave lithotripsy (ESWL), and laparoscopy are widely used.
  • Quantifying the operative invasiveness of these procedures remains a challenge.
  • Systemic inflammatory response, indicated by serum interleukin-6 (IL-6) levels, can serve as a marker for operative invasiveness.

Purpose of the Study:

  • To compare the operative invasiveness of endourology, ESWL, and laparoscopic surgery with open surgery.
  • To evaluate serum IL-6 levels as an indicator of systemic reaction to different surgical procedures.

Main Methods:

  • Serum IL-6 levels were measured in 119 patients.
  • Patients underwent open surgery, laparoscopic surgery, endourology, or ESWL.

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  • IL-6 levels were analyzed to assess systemic response to varying surgical techniques.

    • Main Results:

    • Median IL-6 levels on postoperative day 1 varied significantly across procedures.
    • Open surgery showed the highest median IL-6 level (83.5 pg/mL), followed by laparoscopic surgery (24.8 pg/mL).
    • Endourology and ESWL exhibited the lowest median IL-6 levels (10.8 pg/mL), indicating minimal systemic reaction. Tissue injury and blood loss were identified as key factors influencing IL-6 elevation.

    Conclusions:

    • Endourology, ESWL, and laparoscopic surgery demonstrate significantly lower operative invasiveness.
    • The minimally invasive nature of these procedures is attributed to reduced tissue injury and blood loss.
    • These findings support the use of IL-6 as a reliable biomarker for assessing surgical invasiveness.