Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Extreme exercise and oxidative DNA modification

H E Poulsen1, S Loft, K Vistisen

  • 1Department of Pharmacology, Panum Institute, Copenhagen University, Denmark.

Journal of Sports Sciences
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Birth Cohort Studies of Long-Term Exposure to Ambient Air Pollution in Early Life and Development of Asthma in Children and Adolescents from Denmark.

Research report (Health Effects Institute)·2024
Same author

Long-Term Exposure to AIR Pollution and COVID-19 Mortality and Morbidity in DENmark: Who Is Most Susceptible? (AIRCODEN).

Research report (Health Effects Institute)·2024
Same author

Ultrafine particle exposure for bicycle commutes in rush and non-rush hour traffic: A repeated measures study in Copenhagen, Denmark.

Environmental pollution (Barking, Essex : 1987)·2021
Same author

Exposure to ultrafine particles while walking or bicycling during COVID-19 closures: A repeated measures study in Copenhagen, Denmark.

The Science of the total environment·2021
Same author

Household dampness and microbial exposure related to allergy and respiratory health in Danish adults.

European clinical respiratory journal·2020
Same author

A multisystem composite biomarker as a preliminary diagnostic test in bipolar disorder.

Acta psychiatrica Scandinavica·2018
Same journal

Comparing the effects of small-sided games, skill development, and plyometric training on basketball learning and athletic performance in youth male athletes: A quasi-experimental study.

Journal of sports sciences·2026
Same journal

The effect of sport-specific virtual reality training for soccer players on cognitive performance and related brain processing.

Journal of sports sciences·2026
Same journal

Physical activity as a moderator between problematic social media use and mental health in adolescents.

Journal of sports sciences·2026
Same journal

Transparency Statement.

Journal of sports sciences·2026
Same journal

Partial evidence for fine construct validity of a virtual reality batting test for women's pathway cricketers.

Journal of sports sciences·2026
Same journal

Physical activity, but not sedentary behavior, affects bone mineral density: Insights from a comprehensive genome-wide cross-trait analysis.

Journal of sports sciences·2026
See all related articles

Extreme exercise significantly elevates oxidative DNA damage. This intense physical activity increases the risk of cancer and premature aging due to excessive reactive oxygen species formation.

Area of Science:

  • Exercise physiology
  • Molecular biology
  • Biochemistry

Background:

  • Extreme exercise elevates oxygen consumption, potentially increasing reactive oxygen species (ROS).
  • Antioxidant defenses may be overwhelmed by excessive ROS, leading to biomolecular damage.
  • Oxidative stress is implicated in aging and disease development.

Purpose of the Study:

  • To investigate the impact of prolonged extreme exercise on DNA oxidative modification.
  • To quantify DNA damage markers in athletes undergoing intense training.

Main Methods:

  • 20 men participated in 10 hours of daily vigorous exercise for 30 days.
  • Urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine levels were measured as a marker of DNA oxidation.
  • Statistical analysis was performed to determine the significance of changes.

Related Experiment Videos

Main Results:

  • A 33% increase in the rate of oxidative DNA modification was observed (P < 0.02).
  • Urinary excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine significantly increased.
  • This marker originates from nuclear DNA repair, mitochondrial DNA oxidation, and cell turnover.

Conclusions:

  • Prolonged extreme exercise induces significant oxidative stress to DNA.
  • Increased DNA damage from extreme exercise may elevate risks for cancer and premature aging.
  • Further research is needed to explore mitigation strategies for exercise-induced oxidative stress.