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A model for quantification of perfusion in pulsed labelling techniques

F Calamante¹, S R Williams, N van Bruggen

¹RCS Unit of Biophysics, Institute of Child Health, London, UK.

NMR in Biomedicine

|April 1, 1996

Summary

This study introduces a new model for quantifying blood flow using pulsed labeling techniques. Accurate perfusion quantification requires accounting for differences in relaxation times between blood and tissue to avoid significant overestimation of flow.

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Magnetic Resonance Imaging Quantification of Pulmonary Perfusion using Calibrated Arterial Spin Labeling

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Area of Science:

Magnetic Resonance Imaging
Physiology
Biophysics

Background:

Pulsed labeling techniques in MRI are crucial for quantifying tissue perfusion.
Accurate blood flow measurement is essential for diagnosing various medical conditions.

Purpose of the Study:

To develop and validate a mathematical model for quantifying perfusion using pulsed labeling MRI.
To assess the impact of incorporating blood-tissue relaxation time differences into the perfusion model.

Main Methods:

Solving the modified Bloch equation with flow effects.
Fitting experimental data from two separate measurements (inversion and control/selective and non-selective inversions) with varying inversion times.
Utilizing a biexponential fitting approach.

Main Results:

The proposed model accurately quantifies perfusion in pulsed labeling MRI.
Signal contrast is lower (50%) than continuous labeling but offers advantages for human studies (lower power deposition, shorter transit time, interleaved acquisition).
Including the difference in relaxation time between blood and tissue is critical; neglecting it can lead to overestimations of flow (up to 100% in white matter, 20% in grey matter).

Conclusions:

The developed model provides a robust method for perfusion quantification in pulsed labeling MRI.
The model's suitability for human studies is highlighted due to practical advantages over continuous labeling techniques.
Accurate perfusion quantification necessitates the consideration of differing blood and tissue relaxation times.