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Related Experiment Videos

Plasma paroxonase activity in old age

J R Playfer, C Powell, D A Evans

    Age and Ageing
    |May 1, 1977
    PubMed
    Summary

    Genetic factors influence drug metabolism. This study found that paroxonase activity, a key enzyme, remains unchanged with age, suggesting genetic determinants of drug metabolism are stable throughout life.

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    Area of Science:

    • Pharmacogenetics
    • Biochemistry
    • Gerontology

    Background:

    • Genetic factors significantly impact liver biotransformation of foreign compounds.
    • Aging is associated with increased adverse drug reactions and altered pharmacokinetic parameters.
    • Paroxonase, a liver-synthesized enzyme, is primarily governed by genetic factors, making it a suitable model for age-related gene expression studies.

    Purpose of the Study:

    • To investigate the effect of aging on plasma paroxonase activity.
    • To determine if age-related changes in gene frequency or expression contribute to altered drug responses.
    • To test the hypothesis that genetic determinants of drug metabolism remain constant with age.

    Main Methods:

    • Assessed plasma paroxonase activity in a cohort of 186 elderly individuals.
    • Compared paronase activity frequency distribution with data from 190 blood transfusion volunteers and 189 family members.
    • Analyzed paronase activity as a pharmacogenetic polymorphism.

    Main Results:

    • The frequency distribution of paronase activity in the elderly cohort was similar to that of the younger and family member groups.
    • Paronase activity was found to be unchanged with advancing age.
    • This finding aligns with previous investigations of other pharmacogenetic polymorphisms.

    Conclusions:

    • Plasma paronase activity does not change significantly with age.
    • The study supports the hypothesis that genetic determinants of drug metabolism are stable throughout the lifespan.
    • Age-related changes in drug response are unlikely to be due to alterations in the fundamental genetic makeup of drug-metabolizing enzymes.

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