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Alprazolam-induced hypomania

J Reddy1, S Khanna, U Anand

  • 1Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India.

The Australian and New Zealand Journal of Psychiatry
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

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Alprazolam, a benzodiazepine, may induce hypomania or mania in patients with anxious depression. Symptoms resolved upon alprazolam discontinuation, with no recurrence on other medications.

Area of Science:

  • Psychiatry
  • Pharmacology

Background:

  • Reports suggest a link between alprazolam use and hypomania/mania.
  • This case report investigates a patient experiencing hypomania during alprazolam treatment.

Observation:

  • A patient diagnosed with anxious depression developed hypomania after starting alprazolam.
  • Hypomanic symptoms included euphoria, increased activity, pressured speech, racing thoughts, and sleep disturbance.

Findings:

  • Hypomania resolved upon alprazolam withdrawal.
  • No recurrence of hypomania was observed with fluoxetine or diazepam treatment.

Implications:

  • Alprazolam may possess a distinct mechanism of action compared to other benzodiazepines in inducing hypomania.

Related Experiment Videos

  • Clinicians should monitor patients for hypomania/mania when prescribing alprazolam.