Lithium distribution in experimental inflammation of brain and spinal cord

1. Autoimmune inflammation of the nervous system caused extensive changes in the distribution of lithium injected into rats. 2. Serum lithium levels were greatly increased because of failure of renal excretion caused by pre-renal azotemia, urinary retention and lack of dietary sodium. Brain, spinal cord, pituitary and adrenal levels of lithium were also elevated, reflecting the high serum levels. 3. However, the location and degree of this elevation corresponded to the predominant location of the inflammation. As a result, lithium levels in spinal cord approached and even exceeded the lithium content of brain.