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Related Experiment Videos

Dexfenfluramine lacks amphetamine-like abuse potential

K W Locke1, T R Levesque, K L Nicholson

  • 1Interneuron Pharmaceuticals Inc., Lexington, MA, USA.

Progress in Neuro-Psychopharmacology & Biological Psychiatry
|August 1, 1996
PubMed
Summary
This summary is machine-generated.

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Dexfenfluramine (dFEN) shows no amphetamine-like abuse potential. Studies in rats and monkeys indicate dFEN does not produce reinforcing effects or mimic amphetamine

Area of Science:

  • Pharmacology
  • Neuroscience
  • Addiction Research

Background:

  • Dexfenfluramine (dFEN) is a drug with a complex pharmacological profile.
  • Understanding its abuse potential is crucial for clinical safety and regulatory assessment.

Purpose of the Study:

  • To evaluate the amphetamine-like abuse potential of dexfenfluramine (dFEN).
  • To assess the reinforcing effects of dFEN using established preclinical models.

Main Methods:

  • Drug discrimination assays in Fischer rats trained to distinguish between dFEN or d-amphetamine (dAMP) and saline.
  • Self-administration procedures in rhesus monkeys trained to self-administer cocaine.

Main Results:

  • In rats, dFEN did not substitute for dAMP, and dAMP did not fully substitute for dFEN.

Related Experiment Videos

  • In monkeys, dFEN did not maintain self-administration behavior at rates comparable to cocaine or dAMP.
  • dFEN self-administration patterns resembled saline, indicating minimal reinforcing effects.

    • Conclusions:

    • Dexfenfluramine (dFEN) exhibits a low abuse potential.
    • Preclinical data suggest dFEN is unlikely to produce amphetamine-like abuse liability in humans.