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Whole-brain functional mapping with isotropic MR imaging

V S Mattay1, J A Frank, A K Santha

  • 1Clinical Brain Disorders Branch, National Institutes of Health, National Institute of Mental Health Neuroscience Center at St Elizabeth's, Washington, DC 20032, USA.

Radiology
|November 1, 1996
PubMed
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Gradient-echo, echo-planar magnetic resonance (MR) imaging reliably maps whole-brain activity within subjects. This functional neuroimaging technique shows consistent motor system activation across multiple sessions.

Area of Science:

  • Neuroimaging
  • Functional Magnetic Resonance Imaging (fMRI)
  • Brain Mapping

Background:

  • Accurate within-subject brain mapping is crucial for understanding functional anatomy.
  • Gradient-echo, echo-planar imaging offers potential for rapid, whole-brain data acquisition.

Purpose of the Study:

  • To evaluate the reliability and sensitivity of gradient-echo, isotropic multisection echo-planar MR imaging.
  • To assess its efficacy for within-subject whole-brain functional mapping.

Main Methods:

  • Eight healthy volunteers underwent repeated gradient-echo, echo-planar MR imaging during a motor task over 2-3 months.
  • Acquired 96 whole-brain volumes per session with rigorous statistical thresholding (P < .05, Bonferroni corrected).

Main Results:

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  • Reproducible activation in motor cortical areas and cerebellum was observed in all subjects.
  • 75%-78% of activated voxels were consistently localized to motor areas across sessions.
  • No significant differences in activated voxel proportions or centers of mass were found across sessions.

Conclusions:

  • Isotropic multisection echo-planar MR imaging demonstrates reliability and sensitivity for within-subject functional brain mapping.
  • This noninvasive technique holds potential for accurate mapping of functional anatomy.