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Related Experiment Videos

Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging

H U Kauczor1, D Hofmann, K F Kreitner

  • 1Department of Radiology, Johannes Gutenberg-Universität Mainz, Germany.

Radiology
|November 1, 1996
PubMed
Summary

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Helium-3 magnetic resonance (MR) imaging is feasible for visualizing lung ventilation. This technique successfully depicted normal lungs, lesions, and obstructive lung disease in patients and healthy volunteers.

Area of Science:

  • Medical Imaging
  • Pulmonary Medicine
  • Physics

Background:

  • Magnetic Resonance (MR) imaging is a crucial diagnostic tool.
  • Visualizing lung ventilation with MR imaging presents challenges due to low proton density.
  • Helium-3 (He-3) gas offers potential as a contrast agent for lung MR imaging.

Purpose of the Study:

  • To evaluate the feasibility of using helium-3 (He-3) gas with a three-dimensional fast low-angle shot (FLASH) magnetic resonance (MR) imaging sequence for pulmonary imaging.
  • To assess the ability of He-3 MR imaging to depict normal ventilation, lung lesions, and obstructive lung disease.

Main Methods:

  • Five healthy volunteers and five patients with pulmonary diseases inhaled polarized He-3 gas (300 mL, 3 x 10(5) Pa, up to 45% polarization).
  • Three-dimensional fast low-angle shot (FLASH) MR imaging sequences were employed during breath-hold periods (22-42 seconds).

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  • Image quality and depiction of ventilation patterns were analyzed.

    • Main Results:

    • All breath-hold He-3 MR imaging examinations were successfully completed.
    • Normal lung ventilation was visualized as homogeneous high signal intensity.
    • Lung lesions appeared as signal defects, and obstructive lung disease showed severely inhomogeneous signal intensity.

    Conclusions:

    • Helium-3 magnetic resonance imaging with a 3D FLASH sequence is a feasible technique for assessing lung ventilation.
    • He-3 MR imaging can effectively differentiate between normal ventilation, lung lesions, and patterns of obstructive lung disease.
    • This imaging modality shows promise for non-invasive pulmonary diagnostics.