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Diurnal variation in intragastric pH in children with and without peptic ulcers

A Nagita1, K Amemoto, A Yoden

  • 1Department of Pediatrics, Osaka Medical College, Japan.

Pediatric Research
|October 1, 1996
PubMed

Insights

Intragastric pH monitoring in children reveals distinct patterns in peptic ulcer disease. Gastric ulcer patients show reduced acidity, while duodenal ulcer patients exhibit adult-level acidity, differing from healthy children.

Area of Science:

  • Pediatric Gastroenterology
  • Gastrointestinal Physiology
  • Peptic Ulcer Disease

Background:

  • Diurnal intragastric pH variation in pediatric peptic ulcer disease is uncharacterized.
  • Understanding gastric acidity in children with ulcers is crucial for diagnosis and management.

Purpose of the Study:

  • To investigate the diurnal intragastric pH profiles in children with gastric and duodenal ulcers.
  • To compare gastric acidity between children with ulcers and healthy controls.

Main Methods:

  • 24-hour intragastric pH monitoring using a monopolar glass electrode in 82 subjects.
  • Analysis included children with gastric ulcers, duodenal ulcers, non-ulcer controls, and healthy adults.
  • Calculated percent of readings below pH 2, 3, 4, and 5, comparing means and age-related slopes between groups.

Main Results:

  • In healthy children, gastric acidity increased with age, reaching adult levels by 14 years.
  • Children with gastric ulcers had lower mean intragastric acidity than age-adjusted controls (p < 0.05).
  • Children with duodenal ulcers had significantly higher mean time below pH 2 compared to controls (p = 0.002), with acidity at or above adult levels.

Conclusions:

  • Pediatric gastric ulcers are associated with reduced gastric acidity during childhood.
  • Pediatric duodenal ulcers present with gastric acidity levels comparable to or exceeding adult levels.
  • Age-related changes in gastric acidity differ between children with gastric and duodenal ulcers.

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