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Differentiation induction therapy with all-trans retinoic acid (ATRA) in a patient with secondary 11q23 leukemia
T Kakihara1, A Tanaka, S Kataoka
1Department of Pediatrics, Niigata University School of Medicine, Japan.
Purpose:
Frequently recurrent leukemia is encountered in childhood and is usually resistant to multidrug therapy. We evaluated the efficacy of differentiation induction therapy in a child with leukemia.
Patient And Methods:
We administered all-trans retinoic acid (ATRA) alone, and then a combination of low-dose 1-beta-D-arabinofuranosylcytosine (Ara-C), to a 7-year-old boy who had leukemia secondary to etoposide with chromosomal abnormality 11q23.
Results:
The patient exhibited a good response to ATRA and had a complete remission after combination therapy of ATRA and low-dose Ara-C.
Conclusion:
Differentiation induction therapy with ATRA was effective in treating a patient with recurrence of leukemia without t(15;17) translocation, and which is resistant to conventional cytotoxic treatment.