Hemorrhagic peripapillary lesions in presumed ocular histoplasmosis

Eight eyes of five patients with hemorrhagic peripapillary histoplasmosis demonstrated prolonged symptomatic periods and recurrent bleeding episodes, although final visual acuity was equal to or better than 6/12 (20/40) in five eyes (63%). Fluorescein angiography demonstrated new subretinal neovascular growth at the margins of atrophic scars. In the late stages additional retinal pigment epithelium was lost and a white subretinal mass developed adjacent to the atrophic zone. Argon laser photocoagulation was used in two cases to destroy this neovascular tissue, but caused a permanent arcuate defect in one.