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Related Experiment Videos

Nutrients and intestinal adaptation

A B Thomson1, M Keelan, G E Wild

  • 1Division of Gastroenterology, University of Alberta, Edmonton. alan.thomson@ualberta.ca

Clinical and Investigative Medicine. Medecine Clinique Et Experimentale
|October 1, 1996
PubMed
Summary
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Dietary lipids significantly alter intestinal nutrient transport by changing membrane properties and transporter abundance. Understanding these adaptation mechanisms can guide dietary interventions for disease prevention.

Area of Science:

  • Physiology
  • Cellular Biology
  • Molecular Biology

Background:

  • Intestinal nutrient uptake adapts to dietary changes.
  • Adaptation involves regulating carrier-mediated transport and membrane permeability.
  • Unstirred water layers play a role in nutrient absorption.

Purpose of the Study:

  • To review the physiological, cellular, and molecular mechanisms of intestinal adaptation to dietary lipid content.
  • To explore how dietary lipid manipulations affect sugar and lipid transport.
  • To propose a model for how dietary lipids influence intestinal adaptation.

Main Methods:

  • Review of existing literature on intestinal adaptation.
  • Analysis of nutrient uptake mechanisms, including carrier-mediated and passive transport.

Related Experiment Videos

  • Examination of brush border membrane (BBM) and enterocyte microsomal membrane (EMM) lipid composition and enzyme activity.

    • Main Results:

    • Nutrient uptake is modulated by up- or down-regulation of transport rates and changes in BBM passive permeability (Pd).
    • Altered BBM lipid content affects Pd, linked to changes in EMM lipid-metabolizing enzymes.
    • Dietary lipid changes impact transporter abundance, mRNA levels, and basolateral sodium-potassium adenosine triphosphatase activity.

    Conclusions:

    • Dietary lipid modifications induce significant alterations in intestinal passive and active transport processes.
    • A proposed model suggests dietary lipids stimulate second messengers, affecting gene expression of transporters and enzymes.
    • Understanding intestinal adaptation mechanisms is crucial for developing targeted dietary interventions to prevent disease.