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Related Experiment Videos

Naltrexone and self-injurious behavior: a retrospective population study

J A Casner1, B Weinheimer, C T Gualtieri

  • 1Austin State School, Texas, USA.

Journal of Clinical Psychopharmacology
|October 1, 1996
PubMed
Summary

Naltrexone (NLTX) shows promise for treating self-injurious behavior (SIB) in individuals with intellectual disabilities. Long-term clinical use revealed sustained benefits, with objective responders showing continuous SIB reduction over three years.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Developmental Disabilities

Background:

  • Previous studies on naltrexone (NLTX) for self-injurious behavior (SIB) in individuals with intellectual disabilities yielded inconsistent results.
  • Limited research explored NLTX's efficacy in real-world clinical settings beyond short-term trials with small sample sizes.

Purpose of the Study:

  • To retrospectively evaluate the long-term clinical effectiveness of naltrexone (NLTX) for treating self-injurious behavior (SIB).
  • To assess NLTX's application in a large, diverse patient population within Texas state schools.

Main Methods:

  • Retrospective analysis of clinical data from 56 individuals with SIB treated with NLTX.
  • Inclusion of data from the entire population of Texas state schools (approximately 8,000 individuals).

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  • Application of strict objective response criteria to classify responders.

    • Main Results:

    • Over 50% of individuals treated with NLTX were maintained on the medication due to perceived clinical benefit.
    • 25% of individuals met strict criteria as unequivocal responders to NLTX.
    • Positive response correlated with the level of disability and absence of concurrent aggression.
    • Objective responders demonstrated a consistent, gradual decrease in SIB over time, persisting for over three years.

    Conclusions:

    • Naltrexone (NLTX) can be a viable long-term treatment option for self-injurious behavior (SIB) in individuals with intellectual disabilities.
    • Sustained reduction in SIB was observed in a significant subset of patients, even after extended treatment durations.
    • Further research into predictive factors for NLTX response may optimize treatment strategies for SIB.