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Lung transplantation in infancy and early childhood
N D Bridges1, G B Mallory, C B Huddleston
1Division of Pediatric Cardiology, Children's Hospital of Philadelphia/ University of Pennsylvania School of Medicine 19104, USA.
Insights
Lung transplantation in children under 25 months shows a 71% survival rate, offering a viable option for those with limited life expectancy. Advances in viral illness management may further improve outcomes for pediatric lung transplant recipients.
Area of Science:
- Pediatric surgery
- Thoracic transplantation
- Critical care medicine
Background:
- Lung transplantation in infants and young children presents unique challenges due to their small size and vulnerability.
- Limited rehabilitation and surveillance options further complicate care for this pediatric population.
Purpose of the Study:
- To evaluate the outcomes of lung transplantation in children under 25 months of age.
- To assess the feasibility and survival rates of this procedure in a very young cohort.
Main Methods:
- Retrospective review of 17 patients under 25 months who underwent lung transplantation between July 1990 and February 1995.
- Analysis of patient characteristics, surgical procedures, complications, and survival data.
Main Results:
- Seventy-one percent (12 of 17) hospital survival was achieved, with one late death.
- Early mortality causes included hemorrhage, cytomegalovirus, and viral pneumonitis.
- Surviving patients showed good recovery, normal growth, and no need for supplemental oxygen at 22 months follow-up.
Conclusions:
- Lung transplantation is a viable therapy for very young patients with limited life expectancy and no alternatives.
- Improved management of viral illnesses and early identification of candidates could enhance survival rates in pediatric lung transplantation.
Background:
Experience with lung transplantation in infants and young children is limited. Small size, vulnerability to infection, and limited modalities for rehabilitation and surveillance of the transplanted lung make this group particularly challenging.
Methods:
We reviewed the course of all children up to the age of 25 months who underwent lung transplantation at two centers between July 1990 and February 1995.
Results:
Lung transplantation was performed in 17 patients under the age of 25 months, with concurrent cardiac repair in 14. Prior thoracic surgery had been performed in 12; six patients had mechanical ventilation, and three were supported with extracorporeal membrane oxygenation while waiting for lungs. The mean waiting time was 37 days (range 1 to 197 days). Hospital survival was 12 of 17 (71%); there was one late death. Early deaths were due to hemorrhage (two patients), cytomegalovirus and lymphoproliferative disease (one patients), and viral pneumonitis (two patients). The one late death was due to overwhelming gastroenteritis of unknown origin. One additional patient had graft failure caused by viral pneumonitis and underwent successful retransplantation. Bronchial stenosis occurred at 3 of 33 anastomoses. At a mean follow-up of 22 months, surviving patients were well, without supplemental oxygen, and, although small in stature, had normal linear growth.
Conclusions:
Lung transplantation is a reasonable therapy for very young patients with limited life expectancy and no other therapeutic alternative, with outcomes comparable with those achieved in older patients. Early recognition of lung transplant candidates and advances in the prevention, diagnosis, and treatment of viral illness may improve survival in these patients.