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Human fibroblasts produce "pregnancy-specific" beta-1 glycoprotein in vitro
American Journal of Obstetrics and Gynecology
|August 1, 1979
Abstract:
Normal and genetic variant strains of nonmalignant human fibroblasts produce in vitro a substance indistinguishable from the recently described "pregnancy-specific" beta-1 glycoprotein (PSbetaG, PAPP-C, SP1). Demonstration of this presumed placenta-specific material in a nonplacental site raises questions about its normal physiologic role and use as a cancer marker.

