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Secretion of extracellular proteins by enterohemorrhagic Escherichia coli via a putative type III secretion system
1Center for Vaccine Development, Department of Medicine, University of Maryland, Baltimore 21201, USA.
Infection and Immunity
|November 1, 1996
Abstract:
Enterohemorrhagic and enteropathogenic Escherichia coli (EHEC and EPEC) infections result in attaching and effacing lesions on intestinal epithelial cells. Secretion of extracellular proteins via a type III secretion apparatus is necessary for the formation of attaching and effacing lesions by EPEC. We now show that EHEC also secretes polypeptides via a putative type III secretion system. The secreted EHEC proteins are recognized by rabbit antiserum raised against the proteins secreted from EPEC and by human serum from a patient infected with an EHEC O157:H7 strain.