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Evolutionary rate variation within Mus APRT

D Fieldhouse1, G B Golding

  • 1Department of Biology, McMaster University, Hamilton, ON, Canada.

Genome
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

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Rodent evolution rates vary significantly. Studies show Mus spicilegus exhibits a fivefold faster evolutionary rate around the adenine phosphoribosyltransferase gene compared to Mus musculus, challenging uniform rodent evolutionary speed assumptions.

Area of Science:

  • Evolutionary biology
  • Genomics
  • Mammalian evolution

Background:

  • Rodents are often considered to have high evolutionary rates, approximately double that of other mammalian orders.
  • However, this high rate is not consistently observed across all rodent species, with studies primarily focusing on Mus musculus and Rattus norvegicus.

Purpose of the Study:

  • To investigate the evolutionary rate variation within the rodent order, specifically comparing closely related Mus species.
  • To determine if the adenine phosphoribosyltransferase (APRT) gene shows differential evolutionary rates between Mus spicilegus and Mus musculus.

Main Methods:

  • Phylogenetic analysis using the maximum likelihood algorithm (DNAML).
  • Comparative sequence analysis of the adenine phosphoribosyltransferase (APRT) gene (1100 bp) in Mus spicilegus and Mus musculus.

Related Experiment Videos

  • Detection of evolutionary events directly from APRT gene sequences.

    • Main Results:

    • Mus spicilegus demonstrates a fivefold difference in evolutionary rate around the APRT gene compared to Mus musculus since their divergence.
    • A greater than threefold difference in the number of evolutionary events was detected directly from the APRT sequences of these two species.
    • The close relationship between the studied Mus species allowed for direct detection of evolutionary events.

    Conclusions:

    • Evolutionary rates in rodents are not uniformly high and can vary significantly even between closely related species like Mus spicilegus and Mus musculus.
    • Differences in lifestyle, such as the degree of commensalism with humans, may contribute to observed variations in evolutionary rates.
    • The Mus species serve as a valuable model for exploring the causes of evolutionary rate variation across genes and lineages.