Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Human red cell metabolism and its pathophysiology]

A Hirono1, S Miwa

  • 1Okinaka Memorial Institute for Medical Research.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|September 1, 1996
PubMed
Summary

Red blood cells utilize glycolysis for energy and the hexose monophosphate pathway to produce NADPH, essential for antioxidant defense. Unique pathways like Rapoport-Luebering are vital for red blood cell function and survival.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of lesion length and vessel size on outcomes after sirolimus-eluting stent implantation for in-stent restenosis.

Heart (British Cardiac Society)·2007
Same author

[A case of cervical myeloradiculopathy with positive serum anti-GT1a antibody].

Rinsho shinkeigaku = Clinical neurology·2001
Same author

A new glucose-6-phosphate dehydrogenase variant G6PD Sugao (826C-->T) exhibiting chronic hemolytic anemia with episodes of hemolytic crisis immediately after birth.

International journal of hematology·2001
Same author

Distribution of glucose-6-phosphate dehydrogenase mutations in Southeast Asia.

Human genetics·2001
Same author

Two novel glucose-6-phosphate dehydrogenase variants found in newborn mass-screening for galactosaemia.

European journal of pediatrics·2001
Same author

Hemolytic crisis after excessive ingestion of fava beans in a male infant with G6PD Canton.

International journal of hematology·2000

Area of Science:

  • Biochemistry
  • Cell Biology
  • Hematology

Context:

  • Erythrocytes, or red blood cells, are highly specialized cells with unique metabolic characteristics.
  • Despite lacking a nucleus and mitochondria, red blood cells possess active metabolic pathways crucial for their survival and function.

Purpose:

  • To elucidate the specific metabolic pathways active in erythrocytes.
  • To highlight the significance of these pathways in maintaining red blood cell integrity and function.

Summary:

  • Red blood cells rely on glycolysis as their sole energy-producing pathway.
  • The hexose monophosphate pathway is critical for generating NADPH, which supports the antioxidant system via reduced glutathione.
  • Unique pathways, including the Rapoport-Luebering pathway and the pyrimidine 5'-nucleotide system, are involved in producing 2,3-diphosphoglycerate and processing pyrimidine nucleotides, respectively.

Impact:

  • Understanding erythrocyte metabolism is fundamental to comprehending red blood cell physiology and pathophysiology.
  • This knowledge can inform research into hemolytic anemias and other red blood cell disorders.
  • Highlights the metabolic adaptations enabling red blood cell survival and function in the absence of key organelles.

Related Experiment Videos