Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypothermia in multiple sclerosis

K D White1, D J Scoones, P K Newman

  • 1Department of Neurology, Middlesbrough General Hospital, Cleveland, UK.

Journal of Neurology, Neurosurgery, and Psychiatry
|October 1, 1996
PubMed
Summary

Multiple sclerosis relapses linked to hypothermia in five patients. Hypothalamic lesions were found to cause altered thermoregulation and hypothermia in these cases.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLAs: Key regulators of T-cell-mediated drug hypersensitivity.

HLA·2017
Same author

The visual kinetic depth effect is altered with Parkinson's disease.

Parkinsonism & related disorders·2017
Same author

A full-brain, bootstrapped analysis of diffusion tensor imaging robustly differentiates Parkinson disease from healthy controls.

Neuroinformatics·2014
Same author

Postmortem findings in a case of variant Creutzfeldt-Jakob disease treated with intraventricular pentosan polysulfate.

Journal of neurology, neurosurgery, and psychiatry·2014
Same author

Statistical comparison of heavy metal concentrations in various louisiana sediments.

Environmental monitoring and assessment·2013
Same author

Inertia and memory in ambiguous visual perception.

Cognitive processing·2006

Area of Science:

  • Neurology
  • Neuroimmunology
  • Thermoregulation

Background:

  • Multiple sclerosis (MS) is a chronic autoimmune disease affecting the central nervous system.
  • Thermoregulation disturbances are recognized in MS, but acute hypothermia is rarely reported.
  • The underlying mechanisms of thermoregulatory dysfunction in MS require further elucidation.

Observation:

  • Five patients with clinically definite multiple sclerosis experienced acute relapses coinciding with hypothermia.
  • Four of these patients had recurrent episodes of hypothermia.
  • Thrombocytopenia was noted in conjunction with hypothermia in four patients.

Findings:

  • One patient exhibited chronic hypothermia and an altered thermoregulatory set point.
  • Initial investigations including MRI, endocrine, and autonomic studies did not localize a hypothalamic lesion.
  • Necropsy confirmed hypothalamic lesions, indicating direct or indirect involvement of this brain region.

Implications:

  • Hypothalamic lesions, either direct or affecting outflow pathways, can predispose MS patients to altered thermoregulation and hypothermia.
  • This finding highlights the importance of considering thermoregulatory dysfunction in MS relapses.
  • Further research into hypothalamic involvement in MS pathophysiology is warranted.

Related Experiment Videos