Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Generalised acanthosis nigricans with vitiligo

U Blume-Peytavi1, T Spieker, H Reupke

  • 1Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany.

Acta Dermato-Venereologica
|September 1, 1996
PubMed
Summary

This report details a rare case of inherited generalized acanthosis nigricans and vitiligo in a young woman. The skin condition evolved, with hyperpigmentation progressively replaced by depigmentation due to vitiligo.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Constantin Orfanos.

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

[Not Available].

Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·2016
Same author

Blood group antigen A type 3 expression is a favorable prognostic factor in advanced NSCLC.

Lung cancer (Amsterdam, Netherlands)·2016
Same author

Skin metastases in metastatic uveal melanoma: GNAQ/GNA11 mutational analysis as a valuable tool.

The British journal of dermatology·2013
Same author

High-dose chemotherapy with autologous PBSC transplantation for poor prognosis germ cell tumors: a retrospective monocenter analysis of 44 cases.

Bone marrow transplantation·2012
Same author

Leukemic spleen cells are more potent than bone marrow-derived cells in a transgenic mouse model of CML.

Leukemia·2011

Area of Science:

  • Dermatology
  • Genetics
  • Immunology

Background:

  • Acanthosis nigricans (AN) is a skin condition characterized by hyperpigmentation and thickening, often associated with metabolic disorders or inherited conditions.
  • Vitiligo is an autoimmune disorder causing depigmentation of the skin.
  • The co-occurrence of inherited AN and vitiligo is exceptionally rare.

Observation:

  • A 19-year-old female presented with generalized, inherited acanthosis nigricans since childhood.
  • The characteristic velvety, hyperpigmented lesions evolved into verrucoid papules in body folds.
  • Progressive vitiligo developed, leading to complete depigmentation of the AN lesions.

Findings:

  • This case describes a unique presentation of generalized, pachyderma-like acanthosis nigricans with concurrent vitiligo.

Related Experiment Videos

  • The progression showed a dynamic interplay between hyperpigmentation and depigmentation in the same skin areas.
  • This association has not been previously documented in medical literature.

    • Implications:

    • Highlights a novel association between inherited acanthosis nigricans and vitiligo.
    • Suggests potential shared or interacting pathogenic mechanisms between these distinct dermatoses.
    • Warrants further investigation into the immunological and genetic factors underlying this combined presentation.