Related Experiment Videos
Enhanced in vitro activity of pyrimethamine in combination with dapsone against Mycobacterium avium complex
L M Shah1, S C Meyer, M H Cynamon
1Veterans Affairs Medical Center, Syracuse, New York, USA.
Antimicrobial Agents and Chemotherapy
|October 1, 1996
Abstract:
The in vitro activities of pyrimethamine and dapsone alone and in combination were evaluated against 23 clinical isolates of Mycobacterium avium complex. The broth dilution MICs of dapsone and pyrimethamine alone ranged from 16 to > 64 micrograms/ml. Pyrimethamine in combination with a fixed concentration of dapsone at 0.5 microgram/ml showed enhanced activity, with an MIC range of 0.5 to 16 micrograms/ml.