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Related Experiment Videos

Testosterone and persistence in mice

J Archer

    Animal Behaviour
    |May 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Testosterone administration increased food-searching persistence in male mice, similar to findings in chicks. Training also enhanced persistence, suggesting hormonal and experiential factors influence this behavior.

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    Area of Science:

    • Behavioral Neuroscience
    • Endocrinology
    • Animal Behavior

    Background:

    • Previous research indicates testosterone enhances food-searching persistence in avian species (chicks).
    • The role of testosterone in modulating persistence behaviors in rodents, specifically mice, remains less understood.
    • Understanding hormonal influences on motivated behaviors is crucial for neuroscience and behavioral studies.

    Purpose of the Study:

    • To investigate if testosterone administration enhances food-searching persistence in male mice.
    • To compare the effects of testosterone in castrated mice with intact males and females.
    • To examine the influence of training experience on persistence and compare strain differences in reactivity.

    Main Methods:

    • A factorial experimental design was employed.

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  • A runway test was used to measure food-searching persistence.
  • Mice (castrated and intact males, females) received testosterone or control injections.
  • Two strains of mice (BALB/c and Porton) differing in emotional reactivity were compared.

    • Main Results:

    • Testosterone injection significantly increased persistence in castrated male mice.
    • Intact males showed higher persistence than control-injected castrates, but less than testosterone-injected castrates.
    • Females did not resemble intact males or either castrate group in persistence.
    • Increased training trials positively affected feeding latencies, mimicking testosterone's effect.
    • Differences in persistence were observed between mouse strains, correlating with their emotional reactivity levels.

    Conclusions:

    • Testosterone administration enhances food-searching persistence in male mice.
    • Both hormonal status (testosterone) and experience (training) modulate persistence behaviors.
    • Emotional reactivity of mouse strains influences their performance in persistence tasks.