Growth curves in untreated Ullrich-Turner syndrome: French reference standards 1-22 years

In this retrospective study spanning 22 years, 167 untreated females with Ullrich-Turner syndrome were identified and their case records followed throughout their growth period. Information on total and segmental height and weight was retrieved from the case records and used to plot growth curves. Centiles from birth to adulthood were calculated which showed that the normal pubertal growth spurt was absent. Compared with normal French reference standards, the adult total height deficit was about 21 cm and the adult upper body height deficit was about 15 cm.

Reference curves for untreated Ullrich-Turner syndrome are provided, which should form a basis for assessing the impact of growth-promoting treatment in this disorder.