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Clonal chromosome abnormalities in Fanconi anemia
1INSERM U 301, Institut de Génétique Moléculaire, Paris, France.
Hematology and Cell Therapy
|August 1, 1996
Abstract:
Fanconi anemia (FA) belongs to the chromosomal instability syndromes and frequently evolves toward hematopoietic malignancy. While the recent isolation of one of the genes of FA allows to view to gene therapy, the best treatment is currently bone marrow transplantation. In this review, the data on clonal chromosome abnormalities of FA patients are presented and their significance discussed in the context of the disease.