Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Serum creatine phosphokinase activity in asthma

N K Burki, L Diamond

    The American Review of Respiratory Disease
    |August 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Barriers and enablers in primary care clinicians' management of osteoarthritis: protocol for a systematic review and qualitative evidence synthesis.

    BMJ open·2016
    Same author

    Airway irritation and cough evoked by inhaled cigarette smoke: role of neuronal nicotinic acetylcholine receptors.

    Pulmonary pharmacology & therapeutics·2006
    Same author

    Validation of lymphatic mapping and sentinel node biopsy in patients with symptomatic breast cancer.

    Irish journal of medical science·2006
    Same author

    Carving out a niche.

    Rehab management·2005
    Same author

    CEO/supplier dialogue on patient safety. Panel discussion.

    Health Forum journal·2001
    Same author

    Renal physiology in pig-to-baboon xenografts.

    Transplantation proceedings·2001

    Elevated serum creatine phosphokinase (CPK) levels in asthma patients correlate with symptom severity and airway obstruction. This increase in CPK is attributed to skeletal muscle, likely from respiratory muscles working harder during asthma exacerbations.

    Area of Science:

    • Biochemistry
    • Pulmonology
    • Clinical Medicine

    Background:

    • Asthma is a chronic respiratory disease characterized by airway inflammation and obstruction.
    • Serum creatine phosphokinase (CPK) is an enzyme primarily found in skeletal muscle, heart muscle, and brain.
    • Elevated CPK levels can indicate muscle damage or stress.

    Purpose of the Study:

    • To investigate serum CPK activity in asthma patients.
    • To determine the correlation between CPK levels and asthma severity.
    • To identify the source of elevated CPK in asthma.

    Main Methods:

    • Serum CPK activity was measured in two groups of asthma patients: outpatients and those hospitalized for acute exacerbations.
    • Forced expiratory volume in 1 second (FEV1) was used to objectively measure airway obstruction.

    Related Experiment Videos

  • Creatine phosphokinase isoenzyme analysis was performed to identify the source of elevated CPK.

    • Main Results:

    • Serum CPK activity increased in 8 out of 12 outpatients, correlating with subjective symptoms and reduced FEV1.
    • All 5 hospitalized patients showed increased CPK on admission, which decreased as their condition improved.
    • Elevated CPK was exclusively due to the skeletal muscle isoenzyme, ruling out cardiac origin or relation to therapy, drugs, or hyperthermia.

    Conclusions:

    • Increased serum CPK activity in asthma is likely derived from respiratory muscles due to increased work of breathing during exacerbations.
    • CPK levels may serve as a biomarker for asthma severity and respiratory muscle strain.
    • Further research is warranted to explore the clinical utility of CPK measurements in asthma management.