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The reovirus nonstructural protein sigma1NS is recognized by murine cytotoxic T lymphocytes
L M Hoffman1, K T Hogan, L W Cashdollar
1Department of Microbiology, Medical College of Wisconsin, Milwaukee 53226, USA.
Journal of Virology
|November 1, 1996
Abstract:
The cytotoxic T-lymphocyte (CTL) response in reovirus-infected C3H mice was investigated by using reovirus-vaccinia virus recombinants. Results of cytotoxicity assays indicated that the nonstructural protein sigma1NS elicited a significant CTL response. Experiments with sigma1NS-specific CTL lines showed that both strain-specific and cross-reactive epitopes exist in the sigma1NS protein.