Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human

¹Retrovirus Molecular Biology Group, Department of Biochemistry, University of Oxford, United Kingdom.

|November 1, 1996

Abstract:

We have constructed new murine leukemia virus (MLV)-based vectors (TIN vectors) which, following integration, contain human immunodeficiency virus (HIV) type 1 U3 and R sequences in place of the MLV U3 and R regions. This provides, for the first time, single transcriptional unit retroviral vectors under the control of Tat. TIN vectors have several advantages for anti-HIV gene therapy applications.

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

Optimal clinicogenetic criteria for post-operative re-irradiation in recurrent glioblastoma: KROG 21-02.

ESMO open·2026

Generation of a quasi-Bessel beam with a super-Gaussian axial intensity profile.

Applied optics·2026

Accuracy of artificial intelligence-assisted growth prediction in skeletal Class I preadolescent patients using serial lateral cephalograms for a 2-year growth interval.

Orthodontics & craniofacial research·2024

Adrenalectomy for the treatment of hypotension in a cat with phaeochromocytoma associated with caudal vena cava syndrome.

The Journal of small animal practice·2024

OsCM regulates rice defence system in response to UV light supplemented with drought stress.

Plant biology (Stuttgart, Germany)·2023

Improved Performance of Organic Thermoelectric Generators Through Interfacial Energetics.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2023

See all related articles

Related Experiment Videos

Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human

Related Concept Videos

Optimal clinicogenetic criteria for post-operative re-irradiation in recurrent glioblastoma: KROG 21-02.

Generation of a quasi-Bessel beam with a super-Gaussian axial intensity profile.

Accuracy of artificial intelligence-assisted growth prediction in skeletal Class I preadolescent patients using serial lateral cephalograms for a 2-year growth interval.

Adrenalectomy for the treatment of hypotension in a cat with phaeochromocytoma associated with caudal vena cava syndrome.

OsCM regulates rice defence system in response to UV light supplemented with drought stress.

Improved Performance of Organic Thermoelectric Generators Through Interfacial Energetics.

Humoral response against Epstein-Barr virus follows a strain-specific and HIV-driven pattern.

What a tangled web we weave: how agriculture, a polyphagous insect vector, and rampant recombination drove the emergence, evolution, and economic importance of the geminivirus beet curly top virus in western North America.

Repurposing tretinoin, a vitamin A derivative, against Chikungunya virus infection.

Pre-existing cross-subtype serological responses against H5Nx in health care workers.

A digitally immune-optimized influenza vaccine broadly neutralizes swine and human H1N1 influenza viruses and protects from heterologous challenge.

TLR3-TRIF signaling in villus-like enterocytes drives type III interferon responses to enteroviruses.

Related Experiment Videos

Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human...

Abstract:

Related Concept Videos

Related Articles

Murine leukemia virus-based Tat-inducible long terminal repeat replacement vectors: a new system for anti-human