Vaccination against worm parasites of animals

The 1990s have seen the culmination of decades of painstaking research with the registration and launch of Tickgard (Hoechst), a recombinant vaccine against Boophilus microplus, and the provisional registration of a Taenia ovis vaccine. Research continues to hold promise for immunological control of Echinococcus, Fasciola, Haemonchus, Trichostrongylus and Ostertagia. Blood-sucking parasites (e.g. ticks and H. contortus) are susceptible to control by vaccines containing 'novel' or 'concealed' antigens where serum antibodies in blood meals attack targets in the gut. Antibodies also provide protection in taeniid models, whereas the protective response to be sought in Fasciola remains unclear. More problematic are formulations and delivery strategies to induce expulsion of gastrointestinal nematodes, using vaccines containing recombinant 'conventional' antigens. The use of computer models to simulate vaccine efficacy in worm control and challenges to the concept of 'hypo-responsiveness' of young lambs will encourage cautious optimism and lively debate as to the prospects for integrated worm control using parasite vaccines. This review covers the aspirations, current success and problems faced by researchers in the parasite arena.