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Related Experiment Videos

Pain-evoked potentials: what do they really measure?

R Zaslansky1, E Sprecher, Y Katz

  • 1Institute of Clinical Neurophysiology, Rambam Medical Center, Haifa, Israel.

Electroencephalography and Clinical Neurophysiology
|September 1, 1996
PubMed
Summary

Cerebral evoked potentials (EPs) in response to pain reflect the emotional aspects, not sensory processing. Benzodiazepines, which reduce emotional response but not pain, nearly abolished these EPs, indicating their link to pain

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Area of Science:

  • Neuroscience
  • Pain Research
  • Psychophysiology

Background:

  • Cerebral evoked potentials (EPs) to painful stimuli are traditionally interpreted as objective measures of pain sensation.
  • An alternative view suggests EPs comprise pain-specific and P300 components, reflecting emotional-motivational aspects of pain.

Purpose of the Study:

  • To investigate the nature of pain-evoked cerebral potentials (pain-EPs).
  • To determine if pain-EPs reflect sensory-discriminative or emotional-motivational aspects of pain.

Main Methods:

  • Administered mini doses of benzodiazepines or placebo to 6 healthy volunteers.
  • Measured changes in pain perception and cerebral evoked potentials (EPs).

Main Results:

Related Experiment Videos

  • Benzodiazepines reduced anxiety and diminished the emotional response to pain without altering pain perception.
  • Pain-EPs were almost completely abolished in subjects receiving benzodiazepines.
  • Pain perception remained unchanged.

    • Conclusions:

    • Pain-EPs primarily reflect the emotional-motivational response to pain, not the sensory-discriminative aspects.
    • Pain-EPs serve as a valuable neurophysiological tool for studying pain-related emotions.