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Related Experiment Videos

Age-dependent decrease in embryo implantation rate after in vitro fertilization

R J van Kooij1, C W Looman, J D Habbema

  • 1Department of Reproductive Medicine, University Hospital Utrecht, The Netherlands.

Fertility and Sterility
|November 1, 1996
PubMed
Summary
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Comparison of two models predicting IVF success; the effect of time trends on model performance.

Human reproduction (Oxford, England)·2013

Female age and embryo quality significantly impact in vitro fertilization success rates. After age 37, implantation rates decline sharply, suggesting a biphasic model is most accurate for predicting IVF-ET outcomes.

Area of Science:

  • Reproductive Medicine
  • In Vitro Fertilization
  • Embryology

Background:

  • Implantation rate is a critical metric in assisted reproductive technologies.
  • Female age is a well-established factor influencing fertility outcomes.

Purpose of the Study:

  • To analyze the relationship between female age and embryo implantation rates following in vitro fertilization-embryo transfer (IVF-ET).
  • To identify key factors affecting IVF-ET success beyond maternal age.

Main Methods:

  • Retrospective analysis of IVF-ET data from an academic tertiary care institution.
  • Application of linear and biphasic models within a multivariate analysis framework.
  • Determination of implantation rate based on gestational sacs per embryo replaced, assessed via ultrasound.

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Main Results:

  • Female age and embryo morphology were the strongest predictors of implantation rates.
  • A linear model indicated a ~7% decrease in implantation rate per year of maternal age.
  • A biphasic model demonstrated a significantly steeper decline (>20% yearly) after age 37.

Conclusions:

  • Female age and embryo morphology are the primary independent factors influencing embryo implantation.
  • A biphasic model, with a discontinuity around age 37, best describes the age-related decline in implantation potential.