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The effect of antibody on the migratory pattern of peritoneal macrophages
51Cr-labeled peritoneal macrophages which interiorized sheep erythrocytes (SRBC) injected i.p. into syngeneic recipients accumulate in a typical fashion in different organs. The pattern of distribution can be altered by two maneuvers--when animals at the time of macrophages transfer are injected i.v. with cytophilic antibody, or when macrophages are fed with IgG-SRBC complexes instead of native SRBC. The possible role of modified migratory pattern of macrophages in antibody-induced suppression of the immune response is discussed.
51Cr-labeled peritoneal macrophages which interiorized sheep erythrocytes (SRBC) injected i.p. into syngeneic recipients accumulate in a typical fashion in different organs. The pattern of distribution can be altered by two maneuvers--when animals at the time of macrophages transfer are injected i.v. with cytophilic antibody, or when macrophages are fed with IgG-SRBC complexes instead of native SRBC. The possible role of modified migratory pattern of macrophages in antibody-induced suppression of the immune response is discussed.