Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary neuralgic amyotrophy

P F Chance1, A J Windebank

  • 1Division of Neurology, Children's Hospital of Philadelphia, PA 19104, USA.

Current Opinion in Neurology
|October 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity.

Experimental neurology·2020
Same author

Non-recurrent SEPT9 duplications cause hereditary neuralgic amyotrophy.

Journal of medical genetics·2009
Same author

Mutations in 3 genes (MKS3, CC2D2A and RPGRIP1L) cause COACH syndrome (Joubert syndrome with congenital hepatic fibrosis).

Journal of medical genetics·2009
Same author

SEPT9 gene sequencing analysis reveals recurrent mutations in hereditary neuralgic amyotrophy.

Neurology·2009
Same author

Late-onset hereditary axonal neuropathies.

Neurology·2008
Same author

Dysmorphic syndrome of hereditary neuralgic amyotrophy associated with a SEPT9 gene mutation--a family study.

Clinical genetics·2008
Same journal

Movement disorders and Parkinson's disease: collaborative and interdisciplinary research to advance understanding of neural circuit dysfunction, pathophysiology, and care: new horizons in technology, neuroimaging, neurophysiology, and genetics toward personalized medicine.

Current opinion in neurology·2026
Same journal

Editorial introduction.

Current opinion in neurology·2026
Same journal

Multimodal mapping of balance dysfunction in Parkinson's disease: a consensus roadmap for research and intervention.

Current opinion in neurology·2026
Same journal

Tourette syndrome: brain neurophysiology, circuit dysfunction, and neuromodulation across invasive and noninvasive approaches.

Current opinion in neurology·2026
Same journal

Dystonia: from phenotypes to genetics and therapeutic advances.

Current opinion in neurology·2026
Same journal

What can we learn from eye movements in movement disorders and Parkinson's disease?

Current opinion in neurology·2026
See all related articles

Hereditary neuralgic amyotrophy (HNA) is a painful nerve disorder. Genetic studies have now localized the HNA gene to chromosome 17q24-qter, advancing understanding of this condition.

Area of Science:

  • Genetics
  • Neurology
  • Molecular Biology

Background:

  • Hereditary neuralgic amyotrophy (HNA) is an autosomal dominant disorder characterized by recurrent, painful brachial neuropathies.
  • Some HNA pedigrees exhibit mild facial dysmorphisms, including hypotelorism, a long nasal bridge, and upslanting palpebral fissures.
  • The genetic basis and specific causative gene for HNA remain unidentified.

Purpose of the Study:

  • To identify the chromosomal location of the gene responsible for hereditary neuralgic amyotrophy.
  • To differentiate HNA from clinically similar disorders like hereditary neuropathy with liability to pressure palsies (HNLP).

Main Methods:

  • Genetic linkage studies were performed using polymerase chain reaction (PCR)-based DNA markers.
  • Analysis was conducted across two large pedigrees affected by hereditary neuralgic amyotrophy.

Related Experiment Videos

Main Results:

  • The gene for hereditary neuralgic amyotrophy was successfully localized to the distal long arm of chromosome 17 (17q24-qter).
  • Genetic studies confirmed that HNA and HNLP are distinct disorders, mapping to different chromosomal regions.

Conclusions:

  • The gene responsible for hereditary neuralgic amyotrophy has been localized to chromosome 17q24-qter.
  • This localization provides a crucial step towards identifying the specific gene and understanding the molecular basis of HNA.