Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hypoglycaemia and gastric emptying

C Berne1

  • 1Department of Internal Medicine, University Hospital, Uppsala, Sweden.

Diabetic Medicine : a Journal of the British Diabetic Association
|September 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Organization of trauma management in French level-1 pediatric trauma centers: A cross-sectional survey.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2022
Same author

Effectiveness of screening for diabetes mellitus in dental health care.

Diabetic medicine : a journal of the British Diabetic Association·2012
Same author

The role of obesity-related genetic loci in insulin sensitivity.

Diabetic medicine : a journal of the British Diabetic Association·2012
Same author

Diabetes and impaired glucose tolerance in patients with polycystic ovary syndrome--a long term follow-up.

Human reproduction (Oxford, England)·2011
Same author

Plasma levels of glucagon like peptide-1 associate with diastolic function in elderly men.

Diabetic medicine : a journal of the British Diabetic Association·2011
Same author

Proinsulin/C-peptide ratio, glucagon and remission in new-onset Type 1 diabetes mellitus in young adults.

Diabetic medicine : a journal of the British Diabetic Association·2011
Same journal

Refining metabolic-response signals after liraglutide therapy in type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Finger-stick glucose testing as an institutional stressor: Staff perspectives from long-term care.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Prevalence, duration, and clinical implications of continuous glucose monitor measurement limit capping in type 1 diabetes.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Disentangling the effect of brain insulin resistance on brain health (BIR-BrainHealth): Rationale and study protocol.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Clinical characteristics and in-hospital mortality among insulin pump users with acute coronary syndrome in the predominantly open-loop era: A UK-wide MINAP registry analysis.

Diabetic medicine : a journal of the British Diabetic Association·2026
Same journal

Hyperlipidaemia in youth with type 1 diabetes: Are current guidelines clinically useful?

Diabetic medicine : a journal of the British Diabetic Association·2026
See all related articles

Insulin-induced hypoglycemia accelerates gastric emptying, aiding carbohydrate absorption. Vagal stimulation is key, and impaired responses in diabetic neuropathy may increase hypoglycemia risk.

Area of Science:

  • Gastroenterology
  • Endocrinology
  • Diabetology

Background:

  • Insulin-induced hypoglycemia increases gastric emptying rate for liquids and solids in healthy individuals and short-duration IDDM patients.
  • This physiological response may prevent prolonged hypoglycemia by enhancing carbohydrate absorption.
  • Standardized blood glucose levels are crucial for studying gastric emptying in diabetic patients.

Purpose of the Study:

  • To investigate the role of vagal stimulation in hypoglycemia-induced gastric emptying.
  • To examine the impact of impaired vagal function in diabetic autonomic neuropathy on gastric emptying during hypoglycemia.
  • To understand the implications for glycemic control and hypoglycemia management in diabetes.

Main Methods:

  • Studies involved insulin-induced hypoglycemia in healthy volunteers and IDDM patients.

Related Experiment Videos

  • Cholinergic muscarinic blockade with atropine was used to assess vagal nerve involvement.
  • Plasma pancreatic polypeptide levels were measured to confirm cholinergic blockade.

    • Main Results:

    • Hypoglycemia significantly accelerated gastric emptying.
    • Atropine administration inhibited this acceleration, confirming the role of vagal stimulation.
    • In atropine-treated subjects, pancreatic polypeptide response mimicked that of diabetic patients with autonomic neuropathy.

    Conclusions:

    • Vagal activity, stimulated by hypoglycemia, is a key determinant of gastric emptying rate.
    • Diabetic patients with autonomic neuropathy may have a reduced ability to increase gastric emptying during hypoglycemia, increasing severe hypoglycemia risk.
    • Glycemic influences on vagal activity and gastric emptying affect insulin timing and may be altered by anticholinergic drugs.