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Elevated levels of plasma vasoactive intestinal peptide in human acute myocardial infarction
M Gyöngyösi1, J Németh, T Várkonyi
12nd Department of Internal Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
Insights
Plasma vasoactive intestinal peptide levels rise rapidly within 1 hour of acute myocardial infarction onset in patients. These elevated levels normalize within ten days, indicating VIP as a potential early biomarker for heart attacks.
Area of Science:
- Cardiology
- Endocrinology
- Biochemistry
Background:
- Vasoactive intestinal peptide (VIP) is a peptide hormone with various physiological roles.
- Its role in acute myocardial infarction (AMI) is not fully understood.
Purpose of the Study:
- To investigate the dynamic changes in plasma VIP levels during acute myocardial infarction.
- To assess the potential of VIP as an early diagnostic marker for AMI.
Main Methods:
- Peripheral venous blood samples were collected from patients diagnosed with AMI.
- Plasma VIP concentrations were measured using radioimmunoassay.
- Measurements were taken at different time points: within 1 hour, 2+ hours after symptom onset, and 10 days post-AMI.
Main Results:
- Plasma VIP levels were significantly elevated (P < 0.05) within 1 hour of AMI onset (6.3 ± 0.7 pg/ml) compared to normal levels (2.8 ± 0.9 pg/ml).
- No further increase in VIP levels was observed 2 or more hours after AMI onset.
- VIP levels returned to normal range (3.5 ± 0.5 pg/ml) by 10 days post-AMI.
Conclusions:
- Plasma VIP levels increase rapidly in the early phase of acute myocardial infarction.
- VIP may serve as a sensitive early biomarker for the diagnosis of AMI.
- The transient elevation suggests VIP's involvement in the acute cardiac event.
Abstract:
The plasma levels of vasoactive intestinal peptide in peripheral vein were measured in human acute myocardial infarction. The plasma vasoactive intestinal peptide level was increased within 1 h after the onset of the symptoms of acute myocardial infarction (Group 1, n = 9), compared with normal values (6.3 +/- 0.7 vs. 2.8 +/- 0.9 pg/ml, P < 0.05). Two or more hours after the onset of acute myocardial infarction there was no subsequent increase in peripheral plasma vasoactive intestinal peptide levels (n = 26). Ten days after the onset of acute myocardial infarction, the elevated plasma vasoactive intestinal peptide levels in Group 1 had normalized (3.5 +/- 0.5 pg/ml).