Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Autonomic nervous system function in rheumatoid arthritis. A controlled study

S I Bekkelund¹, R Jorde, G Husby

¹Department of Neurology, University Hospital, Tromsø, Norway.

The Journal of Rheumatology

|October 1, 1996

Summary

Patients with rheumatoid arthritis (RA) show higher levels of pancreatic polypeptide (PP) both fasting and after meals compared to healthy individuals. This study found no link between PP levels and RA disease activity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Hyperglycemia, assessed according to HbA1c , and future risk of venous thromboembolism: the Tromsø study.

Journal of thrombosis and haemostasis : JTH·2014

Same author

Single-nucleotide polymorphism, rs1799941 in the Sex Hormone-Binding Globulin (SHBG) gene, related to both serum testosterone and SHBG levels and the risk of myocardial infarction, type 2 diabetes, cancer and mortality in men: the Tromsø Study.

Andrology·2013

Same author

Neuropsychological functions in systemic lupus erythematosus: a comparison with chronic whiplash patients.

European journal of neurology·2013

Same author

Supplementation with vitamin D does not increase serum testosterone levels in healthy males.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme·2013

Same author

Serum levels of vitamin D are not associated with future risk of venous thromboembolism. The Tromsø Study.

Thrombosis and haemostasis·2013

Same author

Glycated hemoglobin in diagnosis of diabetes mellitus and pre-diabetes; validation by oral glucose tolerance test. The Tromsø OGTT Study.

Journal of endocrinological investigation·2011

Area of Science:

Endocrinology
Rheumatology
Autonomic Neuroscience

Background:

Rheumatoid arthritis (RA) is a chronic inflammatory disease.
Autonomic nervous system dysfunction is common in RA patients.
Pancreatic polypeptide (PP) is a hormone with potential roles in inflammation and metabolism.

Purpose of the Study:

To compare cardiovascular autonomic nervous system functions in RA patients versus controls.
To investigate fasting and postprandial pancreatic polypeptide (PP) levels in RA.
To explore associations between PP levels, autonomic function, and disease activity in RA.

Main Methods:

Study included 43 women with RA and 61 healthy controls.
Cardiovascular autonomic function was assessed via blood pressure and heart rate variability.

Related Experiment Videos

Plasma PP levels were measured using radioimmunoassay before and after a meal.

Main Results:

No significant differences in cardiovascular reflexes between RA patients and controls.
RA patients exhibited significantly higher fasting plasma PP levels (p=0.0006).
Significantly elevated postprandial PP levels were observed in RA patients at 30 and 60 minutes after meal intake (p=0.0001).
No association was found between PP levels and RA disease activity via regression analysis.

Conclusions:

The elevated basal and postprandial PP levels in RA patients suggest a disease-related link.
The underlying mechanisms connecting RA and altered PP levels remain to be elucidated.