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Related Experiment Videos

Diversity and pattern in the developing spinal cord

Y Tanabe1, T M Jessell

  • 1Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biophysics, Center for Neurobiology and Behavior, Columbia University, New York, NY 10032, USA.

Science (New York, N.Y.)
|November 15, 1996
PubMed
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Understanding neuronal cell generation is key to neural circuit assembly and animal behavior. Research reveals molecular mechanisms controlling vertebrate central nervous system development, using the spinal cord as a model.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Molecular Genetics

Background:

  • Neural circuits, essential for animal behavior, arise from distinct neuronal cell types generated in specific numbers and positions.
  • The vertebrate central nervous system (CNS) development involves complex cell diversification and patterning.
  • Advances in molecular genetics and embryology are elucidating the principles governing CNS development.

Purpose of the Study:

  • To review recent advances in understanding the molecular control of CNS development in vertebrates.
  • To highlight the role of specific molecules and transcription factors in neuronal fate determination.
  • To utilize the spinal cord as a model system for studying CNS development.

Main Methods:

  • Molecular genetic assays

Related Experiment Videos

  • Biochemical assays
  • Embryological assays

    • Main Results:

    • Identification of molecules that induce and pattern neural tissue.
    • Elucidation of the mechanisms of action for these patterning molecules.
    • Understanding the role of transcription factors in establishing neuronal identities.

    Conclusions:

    • The spinal cord serves as an effective model for dissecting the molecular control of vertebrate CNS development.
    • Specific molecules and transcription factors play critical roles in neuronal diversification and patterning.
    • Continued research promises deeper insights into the assembly of neural circuits.