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Surgical Retrieval, Isolation and In vitro Expansion of Human Anterior Cruciate Ligament-derived Cells for Tissue Engineering Applications
Published on: April 30, 2014
Salvage of infected total knee components
1Department of Surgery, University of Arizona College of Medicine, Phoenix, USA.
Abstract:
Debridement and retention of components for the treatment of infected total knee replacements has not been effective, with a failure rate of more than 70%. In cases where there are solidly fixed components, particularly with long stems, a method of successfully retaining the components is desirable. A protocol of radical debridement has been developed to eradicate the biofilm related bacteria associated with these infections. Assessment of the interfaces and elimination of all spaces and unsealed interfaces that will allow penetration by bacteria is essential. Four cases of infected total knee replacements are reported without recurrence after a minimum of 18 months. Refinement of the protocol and longer followup on more cases is planned to validate the early results.

